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Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth
BACKGROUND: Children with neurofibromatosis type 1 (NF1) develop optic pathway gliomas, which result from impaired NF1 protein regulation of Ras activity. One obstacle to the implementation of biologically targeted therapies is an incomplete understanding of the individual contributions of the downs...
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| Pubblicato in: | Neuro Oncol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4483119/ https://ncbi.nlm.nih.gov/pubmed/25534823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou329 |
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