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Combination MEK and mTOR inhibitor therapy is active in models of glioblastoma
BACKGROUND: RAS effector signaling pathways such as PI3K/mTOR and ERK are frequently dysregulated in glioblastoma. While small molecule targeted therapies against these pathways have appeared promising in preclinical studies, they have been disappointing in clinical trials due to toxicity and de nov...
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| Publicado no: | Neurooncol Adv |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7668446/ https://ncbi.nlm.nih.gov/pubmed/33235998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa138 |
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