Comparative metabolomics reveals key pathways associated with the synergistic activity of polymyxin B and rifampicin combination against multidrug-resistant Acinetobacter baumannii

Multidrug-resistant (MDR) Acinetobacter baumannii presents a critical challenge to human health worldwide and polymyxins are increasingly used as a last-line therapy. Due to the rapid emergence of resistance during polymyxin monotherapy, synergistic combinations (e.g. with rifampicin) are recommende...

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Udgivet i:Biochem Pharmacol
Main Authors: Zhao, Jinxin, Han, Mei-Ling, Zhu, Yan, Lin, Yu-Wei, Wang, Yi-Wen, Lu, Jing, Hu, Yang, Zhou, Qi Tony, Velkov, Tony, Li, Jian
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7906441/
https://ncbi.nlm.nih.gov/pubmed/33387481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2020.114400
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