Hedgehog proteins create a dynamic cholesterol interface

During formation of the Hedgehog (Hh) signaling proteins, cooperative activities of the Hedgehog INTein (Hint) fold and Sterol Recognition Region (SRR) couple autoproteolysis to cholesterol ligation. The cholesteroylated Hh morphogens play essential roles in embryogenesis, tissue regeneration, and t...

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Vydáno v:PLoS One
Hlavní autoři: Mafi, Amirhossein, Purohit, Rahul, Vielmas, Erika, Lauinger, Alexa R., Lam, Brandon, Cheng, Yu-Shiuan, Zhang, Tianyi, Huang, Yiran, Kim, Soo-Kyung, Goddard, William A., Ondrus, Alison E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7906309/
https://ncbi.nlm.nih.gov/pubmed/33630857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0246814
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