Hedgehog proteins create a dynamic cholesterol interface

During formation of the Hedgehog (Hh) signaling proteins, cooperative activities of the Hedgehog INTein (Hint) fold and Sterol Recognition Region (SRR) couple autoproteolysis to cholesterol ligation. The cholesteroylated Hh morphogens play essential roles in embryogenesis, tissue regeneration, and t...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mafi, Amirhossein, Purohit, Rahul, Vielmas, Erika, Lauinger, Alexa R., Lam, Brandon, Cheng, Yu-Shiuan, Zhang, Tianyi, Huang, Yiran, Kim, Soo-Kyung, Goddard, William A., Ondrus, Alison E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7906309/
https://ncbi.nlm.nih.gov/pubmed/33630857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0246814
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