Site-specific conjugation of native antibody

Traditionally, non-specific chemical conjugations, such as acylation of amines on lysine or alkylation of thiols on cysteines, are widely used; however, they have several shortcomings. First, the lack of site-specificity results in heterogeneous products and irreproducible processes. Second, potenti...

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Bibliografiske detaljer
Udgivet i:Antib Ther
Main Authors: Sadiki, Amissi, Vaidya, Shefali R, Abdollahi, Mina, Bhardwaj, Gunjan, Dolan, Michael E, Turna, Harpreet, Arora, Varnika, Sanjeev, Athul, Robinson, Timothy D, Koid, Andrea, Amin, Aashka, Zhou, Zhaohui Sunny
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Review Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7906296/
https://ncbi.nlm.nih.gov/pubmed/33644685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/abt/tbaa027
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