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ALKBH5-mediated m(6)A demethylation of FOXM1 mRNA promotes progression of uveal melanoma
In this study, we found that ALKBH5, a key component of the N(6)-methyladenosine (m(6)A) methyltransferase complex, was significantly elevated in uveal melanoma (UM) cell lines and that ALKBH5 downregulation inhibited tumor growth in vivo. High ALKBH5 expression predicted worse outcome in patients w...
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| Udgivet i: | Aging (Albany NY) |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Impact Journals
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7906204/ https://ncbi.nlm.nih.gov/pubmed/33428593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.202371 |
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