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Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m(6)A-demethylation of NANOG mRNA

N(6)-methyladenosine (m(6)A) modification of mRNA plays a role in regulating embryonic stem cell pluripotency. However, the physiological signals that determine the balance between methylation and demethylation have not been described, nor have studies addressed the role of m(6)A in cancer stem cell...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Zhang, Chuanzhao, Samanta, Debangshu, Lu, Haiquan, Bullen, John W., Zhang, Huimin, Chen, Ivan, He, Xiaoshun, Semenza, Gregg L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833258/
https://ncbi.nlm.nih.gov/pubmed/27001847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602883113
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