HIF1α epigenetically repressed macrophages via CRISPR/Cas9-EZH2 system for enhanced cancer immunotherapy

Immune suppressive microenvironment in tumor emerges as the main obstacle for cancer immunotherapy. In this study, we identified that HIF1α was activated in the tumor associated macrophages and acted as an important factor for the immune suppressive microenvironment. Epigenetically silencing of Hif1...

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Опубликовано в: :Bioact Mater
Главные авторы: Dong, Yan, Zhang, Siyan, Gao, Xiaotong, Yin, Dandan, Wang, Tingting, Li, Zhelong, Wan, Zhuo, Wei, Mengying, Luo, Ying, Yang, Guodong, Liu, Li
Формат: Artigo
Язык:Inglês
Опубликовано: KeAi Publishing 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7905236/
https://ncbi.nlm.nih.gov/pubmed/33718668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioactmat.2021.02.008
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