HIF1α epigenetically repressed macrophages via CRISPR/Cas9-EZH2 system for enhanced cancer immunotherapy

Immune suppressive microenvironment in tumor emerges as the main obstacle for cancer immunotherapy. In this study, we identified that HIF1α was activated in the tumor associated macrophages and acted as an important factor for the immune suppressive microenvironment. Epigenetically silencing of Hif1...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Bioact Mater
Main Authors: Dong, Yan, Zhang, Siyan, Gao, Xiaotong, Yin, Dandan, Wang, Tingting, Li, Zhelong, Wan, Zhuo, Wei, Mengying, Luo, Ying, Yang, Guodong, Liu, Li
Formato: Artigo
Idioma:Inglês
Publicado em: KeAi Publishing 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7905236/
https://ncbi.nlm.nih.gov/pubmed/33718668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioactmat.2021.02.008
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados