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Genetic reprogramming for NK cell cancer immunotherapy with CRISPR/Cas9

Natural killer cells are potent cytotoxic lymphocytes specialized in recognizing and eliminating transformed cells, and in orchestrating adaptive anti‐tumour immunity. However, NK cells are usually functionally exhausted in the tumour microenvironment. Strategies such as checkpoint blockades are und...

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Bibliografiske detaljer
Udgivet i:Immunology
Main Authors: Afolabi, Lukman O., Adeshakin, Adeleye O., Sani, Musbahu M., Bi, Jiacheng, Wan, Xiaochun
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742769/
https://ncbi.nlm.nih.gov/pubmed/31315144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.13094
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