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Reprogramming MHC specificity by CRISPR-Cas9-assisted cassette exchange

The development of programmable nucleases has enabled the application of new genome engineering strategies for cellular immunotherapy. While targeted nucleases have mostly been used to knock-out or knock-in genes in immune cells, the scarless exchange of entire immunogenomic alleles would be of grea...

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Foilsithe in:Sci Rep
Main Authors: Kelton, William, Waindok, Ann Cathrin, Pesch, Theresa, Pogson, Mark, Ford, Kyle, Parola, Cristina, Reddy, Sai T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379551/
https://ncbi.nlm.nih.gov/pubmed/28374766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45775
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