Antibody discovery and engineering by enhanced CRISPR-Cas9 integration of variable gene cassette libraries in mammalian cells

Antibody engineering in mammalian cells offers the important advantage of expression and screening of libraries in their native conformation, increasing the likelihood of generating candidates with more favorable molecular properties. Major advances in cellular engineering enabled by CRISPR-Cas9 gen...

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Bibliografski detalji
Izdano u:MAbs
Glavni autori: Parola, Cristina, Neumeier, Daniel, Friedensohn, Simon, Csepregi, Lucia, Di Tacchio, Mariangela, Mason, Derek M., Reddy, Sai T.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2019
Teme:
Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816377/
https://ncbi.nlm.nih.gov/pubmed/31478465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1662691
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