High-throughput antibody engineering in mammalian cells by CRISPR/Cas9-mediated homology-directed mutagenesis

Antibody engineering is often performed to improve therapeutic properties by directed evolution, usually by high-throughput screening of phage or yeast display libraries. Engineering antibodies in mammalian cells offer advantages associated with expression in their final therapeutic format (full-len...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Mason, Derek M, Weber, Cédric R, Parola, Cristina, Meng, Simon M, Greiff, Victor, Kelton, William J, Reddy, Sai T
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Synthetic Biology and Bioengineering
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6101513/
https://ncbi.nlm.nih.gov/pubmed/29931269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky550
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