Antibody discovery and engineering by enhanced CRISPR-Cas9 integration of variable gene cassette libraries in mammalian cells

Antibody engineering in mammalian cells offers the important advantage of expression and screening of libraries in their native conformation, increasing the likelihood of generating candidates with more favorable molecular properties. Major advances in cellular engineering enabled by CRISPR-Cas9 gen...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:MAbs
Egile Nagusiak: Parola, Cristina, Neumeier, Daniel, Friedensohn, Simon, Csepregi, Lucia, Di Tacchio, Mariangela, Mason, Derek M., Reddy, Sai T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2019
Gaiak:
Report
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816377/
https://ncbi.nlm.nih.gov/pubmed/31478465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1662691
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