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Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches

Frequent p53 mutations (mutp53) not only abolish tumor suppressor capacities but confer various gain-of-function (GOF) activities that impacts molecules and pathways now regarded as central for tumor development and progression. Although the complete impact of GOF is still far from being fully under...

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發表在:Front Cell Dev Biol
Main Authors: Alvarado-Ortiz, Eduardo, de la Cruz-López, Karen Griselda, Becerril-Rico, Jared, Sarabia-Sánchez, Miguel Angel, Ortiz-Sánchez, Elizabeth, García-Carrancá, Alejandro
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7905058/
https://ncbi.nlm.nih.gov/pubmed/33644030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.607670
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