ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs

SAM68 is an mRNA-binding protein involved in mRNA processing in the nucleus that forms membraneless compartments called SAM68 Nuclear Bodies (SNBs). We found that intersectin 1 (ITSN1), a multidomain scaffold protein harboring five soluble SH3 domains, interacts with SAM68 proline-rich motifs (PRMs)...

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Vydáno v:Cell Mol Life Sci
Hlavní autoři: Pankivskyi, S., Pastré, D., Steiner, E., Joshi, V., Rynditch, A., Hamon, L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904728/
https://ncbi.nlm.nih.gov/pubmed/32780150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-020-03610-y
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