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STRUCTURAL BASIS OF ROBO PROLINE-RICH MOTIF RECOGNITION BY THE SRGAP1 SH3 DOMAIN IN THE SLIT-ROBO SIGNALING PATHWAY
The srGAPs are important components in the intracellular pathway mediating Slit-Robo signaling in axon guidance and cell migration. We report the first crystal structure of the srGAP1 SH3 domain at 1.8 Å resolution. The unusual side chain conformation of the conserved Phe13 in the P1 pocket renders...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2031215/ https://ncbi.nlm.nih.gov/pubmed/16857672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M604135200 |
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