Influence of Cation Transporters (OCTs and MATEs) on the Renal and Hepatobiliary Disposition of [(11)C]Metoclopramide in Mice

PURPOSE: To investigate the role of cation transporters (OCTs, MATEs) in the renal and hepatic disposition of the radiolabeled antiemetic drug [(11)C]metoclopramide in mice with PET. METHODS: PET was performed in wild-type mice after administration of an intravenous microdose (<1 μg) of [(11)C]me...

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Bibliografiske detaljer
Udgivet i:Pharm Res
Main Authors: Hernández-Lozano, Irene, Mairinger, Severin, Sauberer, Michael, Stanek, Johann, Filip, Thomas, Wanek, Thomas, Ciarimboli, Giuliano, Tournier, Nicolas, Langer, Oliver
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2021
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7902338/
https://ncbi.nlm.nih.gov/pubmed/33559045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-021-03002-2
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