Enforced sialyl‐Lewis‐X (sLeX) display in E‐selectin ligands by exofucosylation is dispensable for CD19‐CAR T‐cell activity and bone marrow homing

CD19‐directed chimeric antigen receptors (CAR) T cells induce impressive rates of complete response in advanced B‐cell malignancies, specially in B‐cell acute lymphoblastic leukemia (B‐ALL). However, CAR T‐cell‐treated patients eventually progress due to poor CAR T‐cell persistence and/or disease re...

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Vydáno v:Clin Transl Med
Hlavní autoři: Sánchez‐Martínez, Diego, Gutiérrez‐Agüera, Francisco, Romecin, Paola, Vinyoles, Meritxell, Palomo, Marta, Tirado, Néstor, Zanetti, Samanta Romina, Juan, Manel, Carlet, Michela, Jeremias, Irmela, Menéndez, Pablo
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2021
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901721/
https://ncbi.nlm.nih.gov/pubmed/33634970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.280
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