Enforced sialyl‐Lewis‐X (sLeX) display in E‐selectin ligands by exofucosylation is dispensable for CD19‐CAR T‐cell activity and bone marrow homing

CD19‐directed chimeric antigen receptors (CAR) T cells induce impressive rates of complete response in advanced B‐cell malignancies, specially in B‐cell acute lymphoblastic leukemia (B‐ALL). However, CAR T‐cell‐treated patients eventually progress due to poor CAR T‐cell persistence and/or disease re...

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Bibliografiske detaljer
Udgivet i:Clin Transl Med
Main Authors: Sánchez‐Martínez, Diego, Gutiérrez‐Agüera, Francisco, Romecin, Paola, Vinyoles, Meritxell, Palomo, Marta, Tirado, Néstor, Zanetti, Samanta Romina, Juan, Manel, Carlet, Michela, Jeremias, Irmela, Menéndez, Pablo
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901721/
https://ncbi.nlm.nih.gov/pubmed/33634970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.280
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