Bone marrow MSC from pediatric patients with B-ALL highly immunosuppress T-cell responses but do not compromise CD19-CAR T-cell activity

BACKGROUND: Although adoptive transfer of CD19-directed chimeric antigen receptor (CAR) T-cells (CD19-CAR T-cells) achieves high rates of complete response in patients with B-cell acute lymphoblastic leukemia (B-ALL), relapse is common. Bone marrow (BM) mesenchymal stem/stromal cells (BM-MSC) are ke...

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Bibliografiske detaljer
Udgivet i:J Immunother Cancer
Main Authors: Zanetti, Samanta Romina, Romecin, Paola Alejandra, Vinyoles, Meritxell, Juan, Manel, Fuster, José Luis, Cámos, Mireia, Querol, Sergi, Delgado, Mario, Menendez, Pablo
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2020
Fag:
Immune Cell Therapies and Immune Cell Engineering
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7462245/
https://ncbi.nlm.nih.gov/pubmed/32868394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001419
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