High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability

BACKGROUND: Targeting Protein for Xenopus Kinesin Like Protein 2 (TPX2) is a microtubule associated protein that functions in mitotic spindle assembly. TPX2 also localizes to the nucleus where it functions in DNA damage repair during S-phase. We and others have previously shown that TPX2 RNA levels...

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Bibliografiska uppgifter
I publikationen:BMC Cancer
Huvudupphovsmän: Matson, Daniel R., Denu, Ryan A., Zasadil, Lauren M., Burkard, Mark E., Weaver, Beth A., Flynn, Christopher, Stukenberg, P. Todd
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2021
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901195/
https://ncbi.nlm.nih.gov/pubmed/33622270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-021-07893-7
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