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Cullin neddylation may allosterically tune polyubiquitin chain length and topology
Conjugation of Nedd8 (neddylation) to Cullins (Cul) in Cul-RING E3 ligases (CRLs) stimulates ubiquitination and polyubiquitination of protein substrates. CRL is made up of two Cul-flanked arms: one consists of the substrate-binding and adaptor proteins and the other consists of E2 and Ring-box prote...
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| Publicado no: | Biochem J |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7900908/ https://ncbi.nlm.nih.gov/pubmed/28082425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20160748 |
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