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Familial Mutations May Switch Conformational Preferences in α‑Synuclein Fibrils

The pathogenesis of Parkinson’s disease is closely associated with the aggregation of the α-synuclein protein. Several familial mutants have been identified and shown to affect the aggregation kinetics of α-synuclein through distinct molecular mechanisms. Quantitative evaluation of the relative stab...

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Detalles Bibliográficos
Publicado en:ACS Chem Neurosci
Main Authors: Xu, Liang, Ma, Buyong, Nussinov, Ruth, Thompson, Damien
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900905/
https://ncbi.nlm.nih.gov/pubmed/28075555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00406
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