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Familial Mutations May Switch Conformational Preferences in α‑Synuclein Fibrils
The pathogenesis of Parkinson’s disease is closely associated with the aggregation of the α-synuclein protein. Several familial mutants have been identified and shown to affect the aggregation kinetics of α-synuclein through distinct molecular mechanisms. Quantitative evaluation of the relative stab...
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| Udgivet i: | ACS Chem Neurosci |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7900905/ https://ncbi.nlm.nih.gov/pubmed/28075555 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00406 |
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