Expansion Sequencing: Spatially Precise In Situ Transcriptomics in Intact Biological Systems

Methods for highly multiplexed RNA imaging are limited in spatial resolution, and thus in their ability to localize transcripts to nanoscale and subcellular compartments. We adapt expansion microscopy, which physically expands biological specimens, for long-read untargeted and targeted in situ RNA s...

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Vydáno v:Science
Hlavní autoři: Alon, Shahar, Goodwin, Daniel R, Sinha, Anubhav, Wassie, Asmamaw T, Chen, Fei, Daugharthy, Evan R, Bando, Yosuke, Kajita, Atsushi, Xue, Andrew G, Marrett, Karl, Prior, Robert, Cui, Yi, Payne, Andrew C, Yao, Chun-Chen, Suk, Ho-Jun, Wang, Ru, Yu, Chih-Chieh (Jay), Tillberg, Paul, Reginato, Paul, Pak, Nikita, Liu, Songlei, Punthambaker, Sukanya, Iyer, Eswar P. R., Kohman, Richie E, Miller, Jeremy A, Lein, Ed S, Lako, Ana, Cullen, Nicole, Rodig, Scott, Helvie, Karla, Abravanel, Daniel L, Wagle, Nikhil, Johnson, Bruce E, Klughammer, Johanna, Slyper, Michal, Waldman, Julia, Jané-Valbuena, Judit, Rozenblatt-Rosen, Orit, Regev, Aviv, Church, George M, Marblestone, Adam H, Boyden, Edward S
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900882/
https://ncbi.nlm.nih.gov/pubmed/33509999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax2656
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