AGO-accessible anticancer siRNAs designed with synergistic miRNA-like activity

Small interfering RNAs (siRNAs) therapeutically induce RNA interference (RNAi) of disease-causing genes, but they also silence hundreds of seed-matched off-targets as behaving similar to microRNAs (miRNAs). miRNAs control the pathophysiology of tumors, wherein their accessible binding sites can be s...

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Bibliografiska uppgifter
I publikationen:Mol Ther Nucleic Acids
Huvudupphovsmän: Gu, Dowoon, Ahn, Seung Hyun, Eom, Sangkyeong, Lee, Hye-Sook, Ham, Juyoung, Lee, Dong Ha, Cho, You Kyung, Koh, Yongjun, Ignatova, Elizaveta, Jang, Eun-Sook, Chi, Sung Wook
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Gene & Cell Therapy 2021
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Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900643/
https://ncbi.nlm.nih.gov/pubmed/33664996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2021.01.018
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