Extrahepatic cytochrome P450 epoxygenases: pathophysiology and clinical significance in human gastrointestinal cancers

Cytochrome P450 (CYP) epoxygenases, a multi-gene superfamily of heme-containing enzymes, are commonly known to metabolize endogenous arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs). The role of CYPs is mostly studied in liver drugs metabolism, cardiac pathophysiology, and hypertension fiel...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Pidkovka, Nataliya, Rachkevych, Olena, Belkhiri, Abbes
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2021
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7899545/
https://ncbi.nlm.nih.gov/pubmed/33659048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27893
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