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HLA binding of self-peptides is biased towards proteins with specific molecular functions

Human leukocyte antigen (HLA) is highly polymorphic and plays a key role in guiding adaptive immune responses by presenting foreign and self peptides to T cells. Each HLA variant selects a minor fraction of peptides that match a certain motif required for optimal interaction with the peptide-binding...

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Τόπος έκδοσης:	bioRxiv
Κύριοι συγγραφείς:	Karnaukhov, Vadim, Paes, Wayne, Woodhouse, Isaac B., Partridge, Thomas, Nicastri, Annalisa, Brackenridge, Simon, Scherbinin, Dmitrii, Chudakov, Dmitry M., Zvyagin, Ivan V., Ternette, Nicola, Koohy, Hashem, Borrow, Persephone, Shugay, Mikhail
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Cold Spring Harbor Laboratory 2021
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7899460/ https://ncbi.nlm.nih.gov/pubmed/33619495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.02.16.431395
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HLA binding of self-peptides is biased towards proteins with specific molecular functions

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