HLA binding of self-peptides is biased towards proteins with specific molecular functions

Human leukocyte antigen (HLA) is highly polymorphic and plays a key role in guiding adaptive immune responses by presenting foreign and self peptides to T cells. Each HLA variant selects a minor fraction of peptides that match a certain motif required for optimal interaction with the peptide-binding...

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Publié dans:bioRxiv
Auteurs principaux: Karnaukhov, Vadim, Paes, Wayne, Woodhouse, Isaac B., Partridge, Thomas, Nicastri, Annalisa, Brackenridge, Simon, Scherbinin, Dmitrii, Chudakov, Dmitry M., Zvyagin, Ivan V., Ternette, Nicola, Koohy, Hashem, Borrow, Persephone, Shugay, Mikhail
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7899460/
https://ncbi.nlm.nih.gov/pubmed/33619495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.02.16.431395
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