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cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing
Cyclic GMP–AMP synthase (cGAS) recognition of cytosolic DNA is critical for the immune response to cancer and pathogen infection. Here we discover that cGAS-DNA phase separation is required to resist negative regulation and allow efficient sensing of immunostimulatory DNA. We map the molecular deter...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7899126/ https://ncbi.nlm.nih.gov/pubmed/33606975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.01.024 |
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