Polymeric nanoencapsulation of zaleplon into PLGA nanoparticles for enhanced pharmacokinetics and pharmacological activity

Zaleplon (ZP) is a sedative and hypnotic drug used for the treatment of insomnia. Despite its potent anticonvulsant activity, ZP is not commonly used for the treatment of convulsion since ZP is characterized by its low oral bioavailability as a result of poor solubility and extensive liver metabolis...

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Bibliographic Details
Published in:Biopharm Drug Dispos
Main Authors: Haggag, Yusuf A., Abosalha, Ahmed Kh., Tambuwala, Murtaza M., Osman, Enass Y., El‐Gizawy, Sanaa A., Essa, Ebtessam A., Donia, Ahmed A.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Original Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7898708/
https://ncbi.nlm.nih.gov/pubmed/33320969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdd.2255
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