Polymeric nanoencapsulation of zaleplon into PLGA nanoparticles for enhanced pharmacokinetics and pharmacological activity

Zaleplon (ZP) is a sedative and hypnotic drug used for the treatment of insomnia. Despite its potent anticonvulsant activity, ZP is not commonly used for the treatment of convulsion since ZP is characterized by its low oral bioavailability as a result of poor solubility and extensive liver metabolis...

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Dades bibliogràfiques
Publicat a:Biopharm Drug Dispos
Autors principals: Haggag, Yusuf A., Abosalha, Ahmed Kh., Tambuwala, Murtaza M., Osman, Enass Y., El‐Gizawy, Sanaa A., Essa, Ebtessam A., Donia, Ahmed A.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
Matèries:
Original Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7898708/
https://ncbi.nlm.nih.gov/pubmed/33320969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdd.2255
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