Polymeric nanoencapsulation of zaleplon into PLGA nanoparticles for enhanced pharmacokinetics and pharmacological activity

Zaleplon (ZP) is a sedative and hypnotic drug used for the treatment of insomnia. Despite its potent anticonvulsant activity, ZP is not commonly used for the treatment of convulsion since ZP is characterized by its low oral bioavailability as a result of poor solubility and extensive liver metabolis...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Biopharm Drug Dispos
Autori principali: Haggag, Yusuf A., Abosalha, Ahmed Kh., Tambuwala, Murtaza M., Osman, Enass Y., El‐Gizawy, Sanaa A., Essa, Ebtessam A., Donia, Ahmed A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
Soggetti:
Original Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7898708/
https://ncbi.nlm.nih.gov/pubmed/33320969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdd.2255
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