Polymeric nanoencapsulation of zaleplon into PLGA nanoparticles for enhanced pharmacokinetics and pharmacological activity

Zaleplon (ZP) is a sedative and hypnotic drug used for the treatment of insomnia. Despite its potent anticonvulsant activity, ZP is not commonly used for the treatment of convulsion since ZP is characterized by its low oral bioavailability as a result of poor solubility and extensive liver metabolis...

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Bibliografische gegevens
Gepubliceerd in:Biopharm Drug Dispos
Hoofdauteurs: Haggag, Yusuf A., Abosalha, Ahmed Kh., Tambuwala, Murtaza M., Osman, Enass Y., El‐Gizawy, Sanaa A., Essa, Ebtessam A., Donia, Ahmed A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2021
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Original Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7898708/
https://ncbi.nlm.nih.gov/pubmed/33320969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdd.2255
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