Sirolimus augments hematopoietic stem and progenitor cell regeneration following hematopoietic insults

The role of mammalian target of rapamycin and its suppressor sirolimus in the regulation of hematopoietic stem and progenitor cells (HSPCs) is controversial. We show here that sirolimus enhanced regeneration of HSPCs in mice exposed to sublethal total body irradiation (TBI) and other regenerative st...

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Bibliografische gegevens
Gepubliceerd in:Stem Cells
Hoofdauteurs: Lin, Zenghua, Hollinger, Maile K., Wu, Zhijie, Sun, Wanling, Batey, Kaylind, Kim, Jisoo, Chen, Jichun, Feng, Xingmin, Young, Neal S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Inc. 2020
Onderwerpen:
Translational and Clinical Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7898520/
https://ncbi.nlm.nih.gov/pubmed/33270949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3313
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