Sirolimus augments hematopoietic stem and progenitor cell regeneration following hematopoietic insults

The role of mammalian target of rapamycin and its suppressor sirolimus in the regulation of hematopoietic stem and progenitor cells (HSPCs) is controversial. We show here that sirolimus enhanced regeneration of HSPCs in mice exposed to sublethal total body irradiation (TBI) and other regenerative st...

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Publicat a:Stem Cells
Autors principals: Lin, Zenghua, Hollinger, Maile K., Wu, Zhijie, Sun, Wanling, Batey, Kaylind, Kim, Jisoo, Chen, Jichun, Feng, Xingmin, Young, Neal S.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Inc. 2020
Matèries:
Translational and Clinical Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7898520/
https://ncbi.nlm.nih.gov/pubmed/33270949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3313
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