Sirolimus augments hematopoietic stem and progenitor cell regeneration following hematopoietic insults

The role of mammalian target of rapamycin and its suppressor sirolimus in the regulation of hematopoietic stem and progenitor cells (HSPCs) is controversial. We show here that sirolimus enhanced regeneration of HSPCs in mice exposed to sublethal total body irradiation (TBI) and other regenerative st...

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Vydáno v:Stem Cells
Hlavní autoři: Lin, Zenghua, Hollinger, Maile K., Wu, Zhijie, Sun, Wanling, Batey, Kaylind, Kim, Jisoo, Chen, Jichun, Feng, Xingmin, Young, Neal S.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2020
Témata:
Translational and Clinical Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7898520/
https://ncbi.nlm.nih.gov/pubmed/33270949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3313
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