Abnormal dopamine receptor signaling allows selective therapeutic targeting of neoplastic progenitors in AML patients

The aberrant expression of dopamine receptors (DRDs) in acute myeloid leukemia (AML) cells has encouraged the repurposing of DRD antagonists such as thioridazine (TDZ) as anti-leukemic agents. Here, we access patient cells from a Phase I dose escalation trial to resolve the cellular and molecular ba...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cell Rep Med
Autors principals: Aslostovar, Lili, Boyd, Allison L., Benoit, Yannick D., Di Lu, Justin, Garcia Rodriguez, Juan Luis, Nakanishi, Mio, Porras, Deanna P., Reid, Jennifer C., Mitchell, Ryan R., Leber, Brian, Xenocostas, Anargyros, Foley, Ronan, Bhatia, Mickie
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897800/
https://ncbi.nlm.nih.gov/pubmed/33665638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2021.100202
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars