CXCL12/CXCR4 Signaling Enhances Human PSC-Derived Hematopoietic Progenitor Function and Overcomes Early In Vivo Transplantation Failure

Human pluripotent stem cells (hPSCs) generate hematopoietic progenitor cells (HPCs) but fail to engraft xenograft models used to detect adult/somatic hematopoietic stem cells (HSCs) from donors. Recent progress to derive hPSC-derived HSCs has relied on cell-autonomous forced expression of transcript...

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Publicat a:Stem Cell Reports
Autors principals: Reid, Jennifer C., Tanasijevic, Borko, Golubeva, Diana, Boyd, Allison L., Porras, Deanna P., Collins, Tony J., Bhatia, Mickie
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995456/
https://ncbi.nlm.nih.gov/pubmed/29742393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.04.003
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