Abnormal dopamine receptor signaling allows selective therapeutic targeting of neoplastic progenitors in AML patients

The aberrant expression of dopamine receptors (DRDs) in acute myeloid leukemia (AML) cells has encouraged the repurposing of DRD antagonists such as thioridazine (TDZ) as anti-leukemic agents. Here, we access patient cells from a Phase I dose escalation trial to resolve the cellular and molecular ba...

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Detalhes bibliográficos
Publicado no:Cell Rep Med
Main Authors: Aslostovar, Lili, Boyd, Allison L., Benoit, Yannick D., Di Lu, Justin, Garcia Rodriguez, Juan Luis, Nakanishi, Mio, Porras, Deanna P., Reid, Jennifer C., Mitchell, Ryan R., Leber, Brian, Xenocostas, Anargyros, Foley, Ronan, Bhatia, Mickie
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897800/
https://ncbi.nlm.nih.gov/pubmed/33665638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2021.100202
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