Abnormal dopamine receptor signaling allows selective therapeutic targeting of neoplastic progenitors in AML patients

The aberrant expression of dopamine receptors (DRDs) in acute myeloid leukemia (AML) cells has encouraged the repurposing of DRD antagonists such as thioridazine (TDZ) as anti-leukemic agents. Here, we access patient cells from a Phase I dose escalation trial to resolve the cellular and molecular ba...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cell Rep Med
Main Authors: Aslostovar, Lili, Boyd, Allison L., Benoit, Yannick D., Di Lu, Justin, Garcia Rodriguez, Juan Luis, Nakanishi, Mio, Porras, Deanna P., Reid, Jennifer C., Mitchell, Ryan R., Leber, Brian, Xenocostas, Anargyros, Foley, Ronan, Bhatia, Mickie
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897800/
https://ncbi.nlm.nih.gov/pubmed/33665638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2021.100202
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker