Niche displacement of human leukemic stem cells uniquely allows their competitive replacement with healthy HSPCs

Allogeneic hematopoietic stem cell (HSC) transplantation (HSCT) is currently the leading strategy to manage acute myeloid leukemia (AML). However, treatment-related morbidity limits the patient generalizability of HSCT use, and the survival of leukemic stem cells (LSCs) within protective areas of th...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Boyd, Allison L., Campbell, Clinton J.V., Hopkins, Claudia I., Fiebig-Comyn, Aline, Russell, Jennifer, Ulemek, Jelena, Foley, Ronan, Leber, Brian, Xenocostas, Anargyros, Collins, Tony J., Bhatia, Mickie
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2014
Ämnen:
Brief Definitive Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172227/
https://ncbi.nlm.nih.gov/pubmed/25180064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140131
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