Defective FXR-SHP Regulation in Obesity Aberrantly Increases miR-802 Expression, Promoting Insulin Resistance and Fatty Liver

Aberrantly elevated expression in obesity of microRNAs (miRNAs), including the miRNA miR-802, contributes to obesity-associated metabolic complications, but the mechanisms underlying the elevated expression are unclear. Farnesoid X receptor (FXR), a key regulator of hepatic energy metabolism, has po...

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Bibliographische Detailangaben
Veröffentlicht in:Diabetes
Hauptverfasser: Seok, Sunmi, Sun, Hao, Kim, Young-Chae, Kemper, Byron, Kemper, Jongsook Kim
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2021
Schlagworte:
Obesity Studies
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897352/
https://ncbi.nlm.nih.gov/pubmed/33328206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-0856
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