Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A

Hepatic lipogenesis is normally tightly regulated but is aberrantly elevated in obesity. Fibroblast Growth Factor-15/19 (mouse FGF15, human FGF19) are bile acid-induced late fed-state gut hormones that decrease hepatic lipid levels by unclear mechanisms. We show that FGF15/19 and FGF15/19-activated...

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Publicado en:Nat Commun
Autores principales: Kim, Young-Chae, Seok, Sunmi, Zhang, Yang, Ma, Jian, Kong, Bo, Guo, Grace, Kemper, Byron, Kemper, Jongsook Kim
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686350/
https://ncbi.nlm.nih.gov/pubmed/33235221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19803-9
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