Calculating metalation in cells reveals CobW acquires Co(II) for vitamin B(12) biosynthesis while related proteins prefer Zn(II)

Protein metal-occupancy (metalation) in vivo has been elusive. To address this challenge, the available free energies of metals have recently been determined from the responses of metal sensors. Here, we use these free energy values to develop a metalation-calculator which accounts for inter-metal c...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Young, Tessa R., Martini, Maria Alessandra, Foster, Andrew W., Glasfeld, Arthur, Osman, Deenah, Morton, Richard J., Deery, Evelyne, Warren, Martin J., Robinson, Nigel J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895991/
https://ncbi.nlm.nih.gov/pubmed/33608553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21479-8
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