Calculating metalation in cells reveals CobW acquires Co(II) for vitamin B(12) biosynthesis while related proteins prefer Zn(II)

Protein metal-occupancy (metalation) in vivo has been elusive. To address this challenge, the available free energies of metals have recently been determined from the responses of metal sensors. Here, we use these free energy values to develop a metalation-calculator which accounts for inter-metal c...

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Udgivet i:Nat Commun
Main Authors: Young, Tessa R., Martini, Maria Alessandra, Foster, Andrew W., Glasfeld, Arthur, Osman, Deenah, Morton, Richard J., Deery, Evelyne, Warren, Martin J., Robinson, Nigel J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895991/
https://ncbi.nlm.nih.gov/pubmed/33608553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21479-8
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