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Elevated NSD3 Histone Methylation Activity Drives Squamous Cell Lung Cancer
Amplification of chromosomal region 8p11-12 is a frequent genetic alteration implicated in the etiology of lung squamous cell carcinoma (LUSC)(1-3). FGFR1 (fibroblast growth factor receptor 1) is the main candidate driver within this region(4). However, clinical trials evaluating FGFR1 inhibition as...
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| Veröffentlicht in: | Nature |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7895461/ https://ncbi.nlm.nih.gov/pubmed/33536620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-03170-y |
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