Elevated NSD3 Histone Methylation Activity Drives Squamous Cell Lung Cancer

Amplification of chromosomal region 8p11-12 is a frequent genetic alteration implicated in the etiology of lung squamous cell carcinoma (LUSC)(1-3). FGFR1 (fibroblast growth factor receptor 1) is the main candidate driver within this region(4). However, clinical trials evaluating FGFR1 inhibition as...

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Publicado no:Nature
Main Authors: Yuan, Gang, Flores, Natasha M., Hausmann, Simone, Lofgren, Shane M., Kharchenko, Vladlena, Angulo-Ibanez, Maria, Sengupta, Deepanwita, Lu, Xiaoyin, Czaban, Iwona, Azhibek, Dulat, Vicent, Silvestre, Fischle, Wolfgang, Jaremko, Mariusz, Fang, Bingliang, Wistuba, Ignacio I., Chua, Katrin F., Roth, Jack A., Minna, John D., Shao, Ning-Yi, Jaremko, Łukasz, Mazur, Pawel K., Gozani, Or
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895461/
https://ncbi.nlm.nih.gov/pubmed/33536620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-03170-y
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