Quantification of Cas9 binding and cleavage across diverse guide sequences maps landscapes of target engagement

The RNA-guided nuclease Cas9 has unlocked powerful methods for perturbing both the genome through targeted DNA cleavage and the regulome through targeted DNA binding, but limited biochemical data have hampered efforts to quantitatively model sequence perturbation of target binding and cleavage acros...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Boyle, Evan A., Becker, Winston R., Bai, Hua B., Chen, Janice S., Doudna, Jennifer A., Greenleaf, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895440/
https://ncbi.nlm.nih.gov/pubmed/33608277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe5496
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