Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen

The naked mole rat (NMR), a long-lived and cancer-resistant rodent, is highly resistant to hypoxia. Here, using robust cellular models wherein the mouse telomeric protein TRF1 is substituted by NMR TRF1 or its mutant forms, we show that TRF1 supports maximal glycolytic capacity under low oxygen, sho...

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Publicat a:Sci Adv
Autors principals: Augereau, Adeline, Mariotti, Marco, Pousse, Mélanie, Filipponi, Doria, Libert, Frédérick, Beck, Benjamin, Gorbunova, Vera, Gilson, Eric, Gladyshev, Vadim N.
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895426/
https://ncbi.nlm.nih.gov/pubmed/33608273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe0174
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