Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen

The naked mole rat (NMR), a long-lived and cancer-resistant rodent, is highly resistant to hypoxia. Here, using robust cellular models wherein the mouse telomeric protein TRF1 is substituted by NMR TRF1 or its mutant forms, we show that TRF1 supports maximal glycolytic capacity under low oxygen, sho...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Adv
Päätekijät: Augereau, Adeline, Mariotti, Marco, Pousse, Mélanie, Filipponi, Doria, Libert, Frédérick, Beck, Benjamin, Gorbunova, Vera, Gilson, Eric, Gladyshev, Vadim N.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Association for the Advancement of Science 2021
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895426/
https://ncbi.nlm.nih.gov/pubmed/33608273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe0174
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia