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Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen
The naked mole rat (NMR), a long-lived and cancer-resistant rodent, is highly resistant to hypoxia. Here, using robust cellular models wherein the mouse telomeric protein TRF1 is substituted by NMR TRF1 or its mutant forms, we show that TRF1 supports maximal glycolytic capacity under low oxygen, sho...
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| Vydáno v: | Sci Adv |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Association for the Advancement of Science
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7895426/ https://ncbi.nlm.nih.gov/pubmed/33608273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe0174 |
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