INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform

The naked mole rat (Heterocephalus glaber) is a long-lived and tumor-resistant rodent. Tumor resistance in the naked mole rat is mediated by the extracellular matrix component hyaluronan of very high molecular weight (HMW-HA). HMW-HA triggers hypersensitivity of naked mole rat cells to contact inhib...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Tian, Xiao, Azpurua, Jorge, Ke, Zhonghe, Augereau, Adeline, Zhang, Zhengdong D., Vijg, Jan, Gladyshev, Vadim N., Gorbunova, Vera, Seluanov, Andrei
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313802/
https://ncbi.nlm.nih.gov/pubmed/25550505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418203112
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